Seleccione una sola respuesta salvo que se indique lo contrario.
Especimen
Tumor
Hallazgos adicionales
Biomarcadores de mama
Comentarios
Table 1. Nuclear Grade of Ductal Carcinoma In Situ
| Feature | Grade I (Low) |
Grade II (Intermediate) |
Grade III (High) |
|---|---|---|---|
| Pleomorphism | Monotonous (monomorphic) | Intermediate | Markedly pleomorphic |
| Size | 1.5 to 2 x the size of a normal RBC or a normal duct epithelial cell nucleus | Intermediate | >2.5 x the size of a normal RBC or a normal duct epithelial cell nucleus |
| Chromatin | Usually diffuse, finely dispersed chromatin | Intermediate | Usually vesicular with irregular chromatin distribution |
| Nucleoli | Only occasional | Prominent, often multiple | |
| Mitoses | Only occasional | Intermediate | May be frequent |
| Orientation | Polarized toward luminal spaces | Intermediate | Usually not polarized toward the luminal space |
Definition: RBC, red blood cell.
Distinguishing DCIS from LCIS
| Feature | LCIS | DCIS |
|---|---|---|
| Loss of cohesion | Present | Absent |
| Intracytoplasmic vacuoles | More common | Less common |
| Pagetoid ductal involvement | More common | Less common |
| Microacini | Absent | Present |